Direct contact with mesenchymal stromal cells impacts CD133+ hematopoietic stem cells during ex-vivo expansion

ChEBI2008-11-12 更新2026-07-21 收录

细胞体外扩增

细胞共培养相互作用

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-13566 数据链接链接失效反馈

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Direct contact with mesenchymal stromal cells impacts CD133+ hematopoietic stem cells during ex-vivo expansion

创建时间：

2008-11-12

In vitro Expansion of Hematopoietic Stem Induces Gene Expression Changes

细胞体外扩增

表观遗传调控与基因表达

Hematopoietic stem and progenitor cells (HPCs) can be maintained in vitro, but the vast majority of their progeny loses “stemness” during culture. We have analyzed DNA methylation (DNAm) profiles of f

NIAID Data Ecosystem100

Ex-vivo Human Hematopoietic Stem Cell Expansion Requires Coordination of Cellular Reprogramming with Mitochondrial Remodeling and P53 Activation[10x]

细胞体外扩增

单细胞转录组学

Ex-vivo culture conditions used to expand the numbers of hematopoietic stem cells (HSCs) present within an umbilical cord blood (UCB) unit create cellular stresses leading to loss or at best maintenan

NIAID Data Ecosystem50

Mitochondrial activity linked to CD34+CD90+EPCR+ phenotype determines the functional fitness of ex vivo expanded HSCs. Mitochondrial activity linked to CD34+CD90+EPCR+ phenotype determines the functional fitness of ex vivo expanded HSCs

细胞体外扩增

细胞功能评估

We report the transcritpome of purified CD34+ cells from cultures initiated with cord blood CD34+ hematopoietic stem cells that were expanded ex vivo in Stemline II media supplemented with a cytokine

NIAID Data Ecosystem30

Gene expression changes in passage 1 mesenchymal stem cells from bone marrow stroma during 15 day culturing

细胞体外扩增

时序基因表达分析

To study the gene expression changes in mesenchymal stem cells from bone marrow stroma (MSCs) during in vitro expansion (from low density), passage 1 MSC were grown in culture for 15 days with medium

NIAID Data Ecosystem80

Distinct Stromal Cell Factor Combinations Can Separately Control Hematopoietic Stem Cell Survival, Proliferation and Self-Renewal. Mus musculus

细胞体外扩增

干细胞因子

Hematopoietic stem cells (HSCs) are identified by their ability to sustain prolonged blood cell production in vivo, although recent evidence suggests that durable self-renewal (DSR) is shared by HSC s

NIAID Data Ecosystem40

Direct contact with mesenchymal stromal cells impacts CD133+ hematopoietic stem cells during ex-vivo expansion

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