How an ABO-incompatible graft may contribute to its survival by phenotype-specific glycosylation of the host. A hypothesis.

In contrast to non-nucleated ABO-incompatible red cells, which from a HLA-compatible donor are transfused to a blood group O(H) recipient and undergo immediate destruction, a nucleated, metabolic active tissue that from the same donor is transplanted to the same recipient may,<i> </i>taking into account the effect of all therapeutic measures, occasionally show extreme long survival times. It appears to be established that tissue transplants always maintain their original, phenotype-specific metabolic properties, and expanding the concept of “glycosidic exclusion”, a transplanted ABO-incompatible, metabolically active tissue potentially uses its phenotype-specific enzymatic equipment to contribute to a compatible environment by consistent glycosylation of complementary sites of the plasma proteins and the differentiating B-cell surfaces of a HLA-compatible recipient. <br>

与来自人类白细胞抗原（HLA）相合供者、输注给O(H)血型受者后会发生即刻破坏的无核ABO血型不相合红细胞不同，若将同一供者来源的有核代谢活跃组织移植给同一受者，在综合考量所有治疗措施的影响后，该组织偶尔可表现出极长的存活时长。目前已证实，组织移植始终保留其原始的表型特异性代谢特性；在拓展"糖苷排斥（glycosidic exclusion）"这一概念的语境下，ABO血型不相合且代谢活跃的移植组织，可借助其表型特异性酶系统，通过持续对血浆蛋白以及HLA相合受者分化中B细胞表面的互补位点进行糖基化，进而为受者构建相容的微环境。