Additional file 1 of In search for interplay between stool microRNAs, microbiota and short chain fatty acids in Crohn’s disease - a preliminary study

Additional file 1: Supplementary Table S1. Taxa differentiating patients with active Crohn’s disease from healthy controls. sd - standard deviation, zeroes - number of zeroes in the group, IQR - interquartile range, log2FoldChange - base 2 logarithm from fold-change, stat - Wald’s test statistic, pvalue - unadjusted p-value, padj - FDR adjusted p-value for most abundant taxa, FC - fold-change, Taxonomy - taxonomic assignment, FisherTest - p-value in Fisher’s exact test for taxa prevalence, adjustFisher- FDR adjusted p-value for Fihser’s exact test. Supplementary Table S2. Taxa differentiating patients with inactive Crohn’s disease from healthy controls. sd - standard deviation, zeroes - number of zeroes in the group, IQR - interquartile range, log2FoldChange - base 2 logarithm from fold-change, stat - Wald’s test statistic, pvalue - unadjusted p-value, padj - FDR adjusted p-value for most abundant taxa, FC - fold-change, Taxonomy - taxonomic assignment, FisherTest - p-value in Fisher’s exact test for taxa prevalence, adjustFisher- FDR adjusted p-value for Fihser’s exact test. Supplementary Table S3. Taxa differentiating patients with inactive Crohn’s disease from patients with active disease. sd - standard deviation, zeroes - number of zeroes in the group, IQR - interquartile range, log2FoldChange - base 2 logarithm from fold-change, stat - Wald’s test statistic, pvalue - unadjusted p-value, padj - FDR adjusted p-value for most abundant taxa, FC - fold-change, Taxonomy - taxonomic assignment, FisherTest - p-value in Fisher’s exact test for taxa prevalence, adjustFisher- FDR adjusted p-value for Fihser’s exact test. Supplementary Table S4. SCFA log10 conetrations [ppm] for patients with active, inactive CD and control group. Supplementary Table S4. Error rates for PLS-DA models after M fold model vaildation. Supplementary Table S6. Correlation coefficients’ values for the relevant variables in the whole dataset, rho - Spearman’s correlation coefficient, pvalue - pvalue for the coefficient, padjusted - FDR adjusted pvalue, Taxonomy - taxonomic assignment (if applicable). Supplementary Table SA. GC/MS data.

附加文件1：补充表S1。用于区分活动性克罗恩病（Crohn’s disease, CD）患者与健康对照者的菌群分类群。sd为标准差（standard deviation），zeroes为组内零值数量，IQR为四分位距（interquartile range），log₂FoldChange为以2为底的倍数变化对数值，stat为Wald检验统计量（Wald’s test statistic），pvalue为未校正p值，padj为针对丰度最高分类群的错误发现率（FDR）校正p值，FC为倍数变化，Taxonomy为分类学注释，FisherTest为菌群流行率Fisher精确检验的p值，adjustFisher为Fisher精确检验的FDR校正p值。
补充表S2。用于区分非活动性克罗恩病患者与健康对照者的菌群分类群。sd为标准差（standard deviation），zeroes为组内零值数量，IQR为四分位距（interquartile range），log₂FoldChange为以2为底的倍数变化对数值，stat为Wald检验统计量（Wald’s test statistic），pvalue为未校正p值，padj为针对丰度最高分类群的错误发现率（FDR）校正p值，FC为倍数变化，Taxonomy为分类学注释，FisherTest为菌群流行率Fisher精确检验的p值，adjustFisher为Fisher精确检验的FDR校正p值。
补充表S3。用于区分非活动性克罗恩病患者与活动性克罗恩病患者的菌群分类群。sd为标准差（standard deviation），zeroes为组内零值数量，IQR为四分位距（interquartile range），log₂FoldChange为以2为底的倍数变化对数值，stat为Wald检验统计量（Wald’s test statistic），pvalue为未校正p值，padj为针对丰度最高分类群的错误发现率（FDR）校正p值，FC为倍数变化，Taxonomy为分类学注释，FisherTest为菌群流行率Fisher精确检验的p值，adjustFisher为Fisher精确检验的FDR校正p值。
补充表S4。用于活动性、非活动性克罗恩病患者及健康对照组的短链脂肪酸（SCFA）log₁₀浓度[ppm]。补充表S4。经M折模型验证后的偏最小二乘判别分析（PLS-DA）模型误差率。
补充表S6。全数据集相关变量的相关系数值，rho为斯皮尔曼（Spearman）相关系数，pvalue为该系数的p值，padjusted为错误发现率（FDR）校正p值，Taxonomy为分类学注释（如适用）。
补充表SA。气相色谱-质谱联用（GC/MS）数据。