To investigate the effects of PSENEN knockdown on ?-secretase subunits, biological behaviors, and related signaling pathways in keratinocytes

The present study was designed to use small interfering RNA (siRNA) approach to identify the effects of PSENEN silencing on human immortal keratinocyte cell line, HaCaT. Overall design: The alteration of gene expression profiles after PSENEN gene silencing in HaCaT cells was investigated employing RNA-seq sequencing

本研究旨在采用小干扰RNA（small interfering RNA, siRNA）技术，探究PSENEN基因沉默对人永生化角质形成细胞系HaCaT的影响。总体设计：本研究通过RNA测序（RNA-seq）技术，分析HaCaT细胞中PSENEN基因沉默后的基因表达谱变化。