Supplementary Material for: Hepatitis B and C Virus Infection in the Hemodialysis Population from Three Romanian Regions

<b><i>Background:</i></b> After 10 years of systematically nationwide applied measures for reduction of infection risk, in this national prospective observational study, we reassessed the prevalence of hepatitis virus infection prevalence and its influence on the outcome of end-stage kidney disease (ESKD) patients treated with hemodialysis. <b><i>Methods:</i></b> Six-hundred ESKD patients (332 men and 268 women, median age 56 years) treated with chronic HD in seven centers from all the historical regions of Romania have been assigned to this study on 1st of November 2010. The aims of this study were to reevaluate the prevalence of the hepatitis B and C virus infection in a HD population from Romania after 10 years of systematically nationwide applied measures for reduction of infection risk and also to assess the impact of these infections on the prognosis of HD patients. <b><i>Results:</i></b> HBsAg was positive in 9.5% (n = 57) of the patients, anti-HCV antibodies were detected in 27.3% (n = 164) and 5% (n = 30) were positive for both HBV and HCV infection. The mortality risk was significantly influenced only by age, the presence of coronary artery disease and the 25 OH vitamin D levels. <b><i>Conclusions:</i></b> This study shows that the systematically nationwide applied measures for reduction of infection risk significantly decreased HV infection prevalence in HD patients in Romania. The presence of HV infection did not significantly influence the mortality risk in this population.

**背景：** 在全国系统性实施感染风险降低措施十年后，本项全国性前瞻性观察研究重新评估了肝炎病毒感染患病率，及其对接受血液透析（hemodialysis, HD）治疗的终末期肾病（end-stage kidney disease, ESKD）患者临床结局的影响。
**方法：** 来自罗马尼亚各历史区域的7家医疗中心共纳入600名接受慢性血液透析治疗的终末期肾病患者（其中男性332例，女性268例，中位年龄56岁），纳入时间为2010年11月1日。本研究旨在针对罗马尼亚血液透析人群，在实施十年全国系统性感染风险降低措施后，重新评估乙型肝炎病毒（hepatitis B virus, HBV）与丙型肝炎病毒（hepatitis C virus, HCV）的感染患病率，并同时评估此类感染对血液透析患者预后的影响。
**结果：** 9.5%（n=57）的患者乙肝表面抗原（HBsAg）呈阳性，27.3%（n=164）的患者检出抗丙型肝炎病毒抗体（anti-HCV），另有5%（n=30）的患者同时存在HBV与HCV感染。本研究中，仅年龄、冠状动脉疾病患病情况以及25羟维生素D水平会对患者的死亡风险产生显著影响。
**结论：** 本研究表明，全国系统性推行的感染风险防控措施已使罗马尼亚血液透析患者的肝炎病毒感染患病率显著降低。在此研究人群中，肝炎病毒感染并未对患者的死亡风险产生显著影响。