Supplementary Material for: Risk Factors of Sexual Dysfunction in Patients with Hidradenitis Suppurativa: A Cross-Sectional Study

Background: Hidradenitis suppurativa (HS) has a high impact on quality of life. However, sexual health has scarcely been investigated. Objective: To describe the frequency of sexual dysfunction (SD) in women and erectile dysfunction (ED) in men with HS and to explore potential risk factors. Patients and Methods:We conducted a cross-sectional study using a crowd-sourced online questionnaire spread by the Spanish hidradenitis suppurativa patients’ association (ASENDHI). Results: In total, 393 participants answered the questionnaire. SD was found in 51% (95% CI 45–57%) of women and ED in 60% (95% CI 49–70%) of men. Factors related to SD were education status, patient’s global assessment for disease activity, numeric rating scale for pain and unpleasant odour and the absence of a stable relationship. Factors related to ED were increasing age, the presence of active lesions in the genital area and the number of areas affected by active lesions. Conclusions: There is a high prevalence of SD and ED in HS patients. Being in a stable relationship has been a protective factor of SD in women. The results suggest that sexual impairment in HS patients is due, at least in part, to disease activity, symptoms and active lesions.

背景：化脓性汗腺炎（hidradenitis suppurativa, HS）对患者生活质量影响显著，但目前针对该疾病患者的性健康状况研究甚少。目的：描述化脓性汗腺炎（HS）女性患者的性功能障碍（sexual dysfunction, SD）与男性患者的勃起功能障碍（erectile dysfunction, ED）患病率，并探究潜在危险因素。患者与方法：本研究采用西班牙化脓性汗腺炎患者协会（ASENDHI）推广的众包在线问卷开展横断面研究。结果：共计393名参与者完成问卷。女性患者中SD患病率为51%（95% CI 45%~57%），男性患者中ED患病率为60%（95% CI 49%~70%）。与女性SD相关的因素包括受教育程度、患者对疾病活动度的整体评估、疼痛与异味的数字评定量表评分，以及无稳定伴侣关系。与男性ED相关的因素包括年龄增长、生殖器部位存在活动性皮损，以及受累活动性皮损区域数量。结论：化脓性汗腺炎（HS）患者的SD与ED患病率均较高。拥有稳定伴侣关系是女性发生SD的保护因素。研究结果提示，HS患者的性功能受损至少部分源于疾病活动度、相关症状及活动性皮损。