Echocardiography of HGF tg mice.

Wild-type: littermate wild-type control; HGF tg: bitransgenic mice conceived in the absence of DOX; prenatal HGF tg: bitransgenic mice treated with DOX at birth and maintained in DOX thereafter; silent HGF and α-MHC-tTA: littermate single transgenics. FS, fractional shortening; IVSTd, interventricular septum thickness in end diastole; LVEDD, left ventricle end diastolic diameter; PWTd, posterior wall thickness in end diastole; IVSTs, interventricular septum thickness in end systole; LVESD, left ventricle end systolic diameter; PWTs, posterior wall thickness in end systole; h/r, heart rate; HW, heart weight; BW, body weight; HW/BW, heart weight/body weight ratio. n.d., not determined.*p

野生型（Wild-type）：同窝野生型对照；肝细胞生长因子转基因（HGF tg）：无DOX诱导条件下构建的双转基因小鼠；产前肝细胞生长因子转基因（prenatal HGF tg）：出生时予以DOX干预并后续持续维持DOX给药的双转基因小鼠；沉默型肝细胞生长因子与α-肌球蛋白重链-四环素反式激活因子（α-MHC-tTA）：同窝单转基因小鼠。短轴缩短率（FS, fractional shortening）；舒张末期室间隔厚度（IVSTd, interventricular septum thickness in end diastole）；左心室舒张末期内径（LVEDD, left ventricle end diastolic diameter）；舒张末期左心室后壁厚度（PWTd, posterior wall thickness in end diastole）；收缩末期室间隔厚度（IVSTs, interventricular septum thickness in end systole）；左心室收缩末期内径（LVESD, left ventricle end systolic diameter）；收缩末期左心室后壁厚度（PWTs, posterior wall thickness in end systole）；心率（h/r, heart rate）；心脏重量（HW, heart weight）；体质量（BW, body weight）；心脏重量/体质量比值（HW/BW, heart weight/body weight ratio）；未检测（n.d., not determined）。*p