Stratified logistic regression analysis.

ObjectiveAdded sugars have been associated with a variety of adverse health consequences, but their relationship with osteoarthritis is unclear. This study aimed to demonstrate the association between added sugars and osteoarthritis.MethodsWe used the National Health and Nutrition Examination Survey (NHANES) database from 2007 to 2018 to explore the association between added sugars and osteoarthritis.ResultsIn our study, 2,746 adults were included. The average age of the chosen participants was 43.77 years, with 52.33% males and 47.67% females. There were 2,152 in the osteoarthritis group and 594 in the non-osteoarthritis group, weighted to represent 11,854,966 participants. In the fully adjusted multivariable model 3, added sugars were found as a risk factor for osteoarthritis (OR = 1.01; 95% CI 1.00 to 1.01), with populations in the fourth quartile having a greater prevalence of osteoarthritis (OR = 1.40; 95% CI 1.09 to 1.81). When added sugars were treated as a continuous variable in subgroup analysis, the results indicated that never consumed alcohol (OR = 1.02; 95% CI 1.01 to 1.04) and no history of diabetes (OR = 1.02; 95% CI 1.01 to 1.04)were more Likely tend to osteoarthritis. When added sugars were treated as a categorical variable in subgroup analysis, the results indicated that compared to the first group, in the fourth quartile population, females (OR = 1.44; 95% CI 1.02 to 2.02), low BMI (OR = 1.88; 95% CI 1.06 to 3.33), never smoking (OR = 1.55; 95% CI 1.05 to 2.30), never consumed alcohol (OR = 3.31; 95% CI 1.42 to 7.74), no history of hypertension (OR = 1.51; 95% CI 1.00 to 2.27), and no history of diabetes (OR = 1.44; 95% CI 1.11 to 1.87) were more likely tend to osteoarthritis.ConclusionAdded sugars are a risk factor for osteoarthritis, especially in females, low BMI, never smoking, never consumed alcohol, no history of hypertension, and no history of diabetes.

添加糖（added sugars）与多种不良健康结局相关，但其与骨关节炎（osteoarthritis）的关联尚不明确。本研究旨在阐明添加糖与骨关节炎之间的关联。

方法 本研究采用2007至2018年全国健康与营养调查（National Health and Nutrition Examination Survey, NHANES）数据库，探究添加糖与骨关节炎的关联。

结果 本研究共纳入2746名成人，入选参与者的平均年龄为43.77岁，其中男性占52.33%，女性占47.67%。骨关节炎组共2152例，非骨关节炎组594例，经加权后对应总体人群11854966名参与者。在完全校正的多变量模型3中，添加糖被证实为骨关节炎的危险因素（比值比（odds ratio, OR）=1.01；95%置信区间（confidence interval, CI）：1.00~1.01），处于第四分位数的人群骨关节炎患病率更高（OR=1.40；95%CI：1.09~1.81）。当将添加糖作为连续变量进行亚组分析时，结果显示从不饮酒（OR=1.02；95%CI：1.01~1.04）及无糖尿病病史（OR=1.02；95%CI：1.01~1.04）人群更易罹患骨关节炎。当将添加糖作为分类变量进行亚组分析时，结果显示，与第一分位数组相比，第四分位数人群中，女性（OR=1.44；95%CI：1.02~2.02）、低体质量指数（Body Mass Index, BMI）人群（OR=1.88；95%CI：1.06~3.33）、从不吸烟者（OR=1.55；95%CI：1.05~2.30）、从不饮酒者（OR=3.31；95%CI：1.42~7.74）、无高血压病史者（OR=1.51；95%CI：1.00~2.27）及无糖尿病病史者（OR=1.44；95%CI：1.11~1.87）更易罹患骨关节炎。

结论 添加糖是骨关节炎的危险因素，尤其在女性、低BMI人群、从不吸烟者、从不饮酒者、无高血压病史及无糖尿病病史人群中更为显著。