The associations between Galaxolide and SNPs of other reported musk-related ORs in the discovery cohort (n = 1000) before controlling for the top associated variants (SNPs in OR4D6).

OR5AN1 and OR5A2 are in the same LD-band as OR4D6 (see main Fig 2.), meaning variants in these ORs are more likely to be inherited with the SNPs from OR4D6. After performing an additional analysis controlling for the top associated SNPs in OR4D6 (p-value after controlling for top SNP), we found no additional significant signal. (XLSX)

OR5AN1与OR5A2与OR4D6处于同一连锁不平衡区段（Linkage Disequilibrium band, LD-band，详见主文图2），这意味着上述两个嗅觉受体基因的变异与OR4D6的单核苷酸多态性（Single Nucleotide Polymorphism, SNP）更易共同遗传。在针对OR4D6中最强关联的单核苷酸多态性位点开展校正分析后（校正顶级SNP后的p值），本研究未检测到额外的显著信号。（XLSX）