Intermolecular/Intramolecular Sequential Aldol Reaction

The first example of intermolecular/intramolecular
sequential aldol
reaction of disilyl enol ethers is described. This strategy enables
the formation of five-, six-, and seven-membered ring products. Four
or more contiguous stereogenic centers are created with high levels
of relative stereochemical control.

本工作首次报道了二硅基烯醇醚（disilyl enol ethers）的分子间/分子内顺序羟醛缩合反应（sequential aldol reaction）。该策略可构建五元、六元及七元环产物。该反应可生成四个及以上连续手性中心，并实现高水平的相对立体化学控制。