PNI hemodialysis PLOS one data.xlsx

<b>Background:</b> End-stage renal disease (ESRD) patients frequently experience protein-energy wasting (PEW), which increases their morbidity and mortality rates.<b>Objective:</b> This study explores the effects of nutritional status and pulmonary function on the short- and long-term mortality of ESRD patients undergoing hemodialysis.<b>Materials and Methods:</b> 67 consecutive ESRD patients on maintenance hemodialysis were included in the study. The primary outcomes were all-cause one-year and five-year mortality. Data on demographic characteristics, comorbidities, and laboratory findings were collected. Pulmonary function tests were conducted along with body composition measurements using bioelectrical impedance analysis (BIA). Malnutrition was assessed using the Prognostic Nutritional Index (PNI).<b>Results:</b> The median age of the patients was 60.9 ± 12.4 years, with 58.3% being male. Pulmonary function parameters (FEV1 and FVC) were significantly associated with short-term mortality. The PNI was a significant predictor of both short-term and long-term mortality. A PNI score ≤ 39.01 was associated with increased short-term mortality (HR: 0.65, 95% CI: 0.48-0.88, p = 0.006), while a score ≤ 40 was linked to increased long-term mortality (HR: 0.80, 95% CI: 0.67-0.95, p = 0.015). Additionally, older age (HR: 1.06, 95% CI: 1.01-1.12, p = 0.021) and higher glomerular filtration rate (GFR) (HR: 1.23, 95% CI: 1.02-1.42, p = 0.024) were related to increased long-term mortality risk.<b>Conclusion:</b> The study demonstrates that PNI, age, and pulmonary function are critical factors influencing the survival of hemodialysis patients. These findings underscore the importance of comprehensive nutritional and pulmonary assessment to improve clinical outcomes in this population.

<b>背景：</b>终末期肾病（End-stage renal disease, ESRD）患者常发生蛋白质-能量消耗（protein-energy wasting, PEW），这会增加其发病率和死亡率。<b>目的：</b>本研究探讨营养状况和肺功能对接受血液透析的ESRD患者短期及长期死亡率的影响。<b>材料与方法：</b>本研究纳入67例连续接受维持性血液透析的ESRD患者。主要结局指标为全因1年及5年死亡率。收集患者人口统计学特征、合并症及实验室检查数据。进行肺功能测试，并采用生物电阻抗分析（bioelectrical impedance analysis, BIA）测量身体成分。采用预后营养指数（Prognostic Nutritional Index, PNI）评估营养不良状况。<b>结果：</b>患者中位年龄为60.9±12.4岁，其中58.3%为男性。肺功能参数（FEV1和FVC）与短期死亡率显著相关。PNI是短期和长期死亡率的显著预测因子。PNI评分≤39.01与短期死亡率升高相关（HR：0.65，95%CI：0.48-0.88，p=0.006），而评分≤40与长期死亡率升高相关（HR：0.80，95%CI：0.67-0.95，p=0.015）。此外，年龄较大（HR：1.06，95%CI：1.01-1.12，p=0.021）和肾小球滤过率（GFR）较高（HR：1.23，95%CI：1.02-1.42，p=0.024）与长期死亡风险增加相关。<b>结论：</b>本研究表明，PNI、年龄和肺功能是影响血液透析患者生存的关键因素。这些发现强调了全面营养和肺功能评估对改善该人群临床结局的重要性。