Supplementary Material for: Triple Negative Breast Cancer versus Non-Triple Negative Breast Cancer Treated with Breast Conservation Surgery Followed by Radiotherapy: A Systematic Review and Meta-Analysis

<b><i>Background:</i></b> The aim of this study was to compare the efficacy of breast conservation surgery (BCS) followed by radiotherapy (RT) in triple negative breast cancer (TNBC) versus non-TNBC. <b><i>Methods:</i></b> We searched the MEDLINE and EMBASE databases from inception through March 31, 2014, using search terms related to TNBC, BCS, and RT. Studies comparing the efficacy of BCS followed by RT in TNBC versus non-TNBC were reviewed. <b><i>Results:</i></b> 5 studies including 2,922 non-TNBC and 510 TNBC cases were selected. The overall quality of included studies was deemed moderate to high. Compared with non-TNBC, the pooled relative risk of 5-year local relapse-free survival was 1.315 (95% confidence interval (CI) 0.967-1.789; p = 0.008) for TNBC, and that of 5-year overall survival, regional relapse-free survival, and distant metastasis-free survival was 1.929 (95% CI 1.392-2.674; p = 0.000), 3.052 (95% CI 1.629-5.715; p = 0.000), and 2.407 (95% CI 1.910-3.034; p = 0.000), respectively. <b><i>Conclusion:</i></b> The local control rate of TNBC treated with BCS plus RT is similar to that of non-TNBC.

**背景**：本研究旨在对比三阴性乳腺癌（triple negative breast cancer, TNBC）患者接受乳腺癌保乳手术（breast conservation surgery, BCS）联合放射治疗（radiotherapy, RT）的疗效与非三阴性乳腺癌患者的疗效差异。
**方法**：检索MEDLINE与EMBASE数据库自建库至2014年3月31日的文献，检索词涵盖TNBC、BCS及RT相关主题，最终纳入对比TNBC与非TNBC患者接受BCS联合RT疗效的相关研究进行系统回顾。
**结果**：最终纳入5项研究，共包含2922例非TNBC患者与510例TNBC患者；纳入研究的整体质量等级为中至高。与非TNBC患者相比，TNBC患者的5年局部无复发生存率合并相对风险为1.315（95%置信区间（confidence interval, CI）0.967~1.789；P=0.008）；5年总生存率、区域无复发生存率及远处无转移生存率的合并相对风险分别为1.929（95%CI 1.392~2.674；P=0.000）、3.052（95%CI 1.629~5.715；P=0.000）与2.407（95%CI 1.910~3.034；P=0.000）。
**结论**：接受BCS联合RT治疗的TNBC患者局部控制率与非TNBC患者相当。