Chronic hypoxic response in rod photoreceptors

In this study, we address the underlying cause of photoreceptor degeneration by focusing on alterations in energy metabolism during chronic HIF activation. Using layer-specific proteomics, we analyzed proteome alterations in photoreceptor segments and cell bodies upon chronic HIF activation.

本研究以慢性缺氧诱导因子（Hypoxia-Inducible Factor, HIF）激活过程中的能量代谢改变为切入点，旨在阐明光感受器变性的潜在致病机制。研究采用分层蛋白质组学（layer-specific proteomics）技术，分析了慢性缺氧诱导因子激活后光感受器节段与细胞体的蛋白质组变化。