Researcher Project: Interplay between Environmental Contaminants, Genes and Diet in Obesity (1/3), 2014.

This dataset consists of data from "Researcher Project: Interplay between Environmental Contaminants, Genes and Diet in Obesity, 2014". The prevalence of both obesity and colorectal cancer has increased substantially in the last decades. Simultaneously have humans been exposed to increasing amounts of environmental contaminants. This project studies fundamental questions related to the interplay between environmental contaminants, genes and health outcomes, obesity and intestinal cancer in mouse models. Mechanisms for how obesity affects intestinal tumorigenesis and how environmental contaminants may contribute to obesity were studied along two main hypotheses, via insulin resistance/hyperinsulinemia and/or inflammation. The project aims to increase the understanding of the mutual causal relationship between obesity and susceptibility for environmental contaminants, causing intestinal cancer. The results will also be useful in human risk assessment of substances such as perfluorooctanoic acid, for which data on toxic effects and dose-response relationships are still lacking.

The project includes three subprojects (publications). This dataset consists of data from the first subproject.

本数据集包含"研究者项目：2014年环境污染物、基因与饮食在肥胖中的相互作用"的数据。近几十年来，肥胖和结直肠癌的患病率均显著上升。与此同时，人类接触到的环境污染物数量也在不断增加。本项目以小鼠模型为研究对象，探讨环境污染物、基因与健康结局（肥胖和肠癌）之间相互作用的基础问题。研究人员围绕两个主要假设（通过胰岛素抵抗/高胰岛素血症（insulin resistance/hyperinsulinemia）和/或炎症途径），探究肥胖影响肠道肿瘤发生（intestinal tumorigenesis）的机制，以及环境污染物可能导致肥胖的机制。本项目旨在增进对肥胖与环境污染物易感性之间相互因果关系的理解，这种关系会导致肠癌的发生。研究结果还将有助于全氟辛酸（perfluorooctanoic acid）等物质的人类风险评估，目前这些物质的毒性效应和剂量-反应关系（dose-response relationships）数据仍较为缺乏。

该项目包含三个子项目（已发表成果）。本数据集为第一个子项目的数据。