Activity of human neural crest enhancer near FAM222A in E11.5 transgenic mouse embryo – Tg(hg38_chr12:109709145-109709901::LacZ).

Tg(hg38_chr12:109709145-109709901::LacZ) human neural crest enhancer with biased activity in the frontonasal prominence, facial (VII)/vestibulocochlear (VIII) ganglia, heart field, and medial forelimb buds when compared to the orthologous chimp enhancer. Transgenic embryos also show reproducible activity In the midbrain, periocular mesenchyme/optic cup, and floor plate of the neural tube that overlaps with the chimp enhancer-driven LacZ expression.

Tg(hg38_chr12:109709145-109709901::LacZ)人类神经嵴增强子，与黑猩猩同源增强子相比，在额鼻突、面（VII）/前庭蜗（VIII）神经节、心脏区域及前肢芽内侧具有偏向性活性。转基因胚胎还在中脑、眼周间质/视杯及神经管底板中表现出可重复的活性，这些区域与黑猩猩增强子驱动的LacZ表达区域重叠。