Global transcriptome analysis of the Aspergillus fumigatus Mitogen Activated Protein Kinases SakAHOG1 and MpkC exposed to osmotic stress reveals regulators of osmotic and cell wall stresses

A. fumigatus MpkC and SakA, homologues of the Saccharomyces cerevisiae Hog1, constitute the main regulator of the HOG ((High Osmolarity Glycerol)) pathway. The present study investigated the early transcriptional response of A. fumigatus to osmotic stress. We compared the A. fumigatus wild-type transcriptional response to osmotic stress with and ?mpkC, ?sakA, and ?mpkC ?sakA mutant strains.

烟曲霉（A. fumigatus）的MpkC与SakA为酿酒酵母（Saccharomyces cerevisiae）Hog1的同源蛋白，二者构成高渗甘油（High Osmolarity Glycerol, HOG）信号通路的主要调控因子。本研究探究了烟曲霉对渗透胁迫的早期转录应答。我们将烟曲霉野生型菌株在渗透胁迫下的转录应答，与ΔmpkC、ΔsakA及ΔmpkC ΔsakA突变菌株的转录应答进行了比较。