RNAseq transcriptome analysis of White Blood Cells (WBCs) from individuals with and without trisomy 21 [unstranded]

Poly(A)+ RNA extracted from WBCs obtained from chromosome 21 disomic (D21) and trisomic (T21) individuals to identify consistent changes in gene expression across individuals. Overall design: 2 individuals with T21 and 3 individuals with D21.

本研究从21号染色体二体（D21）与三体（T21）个体的白细胞（White Blood Cells, WBCs）中提取多聚腺苷酸化RNA（Poly(A)+ RNA），旨在鉴定不同个体间一致的基因表达变化。实验设计概述：纳入2例21号染色体三体个体与3例21号染色体二体个体。