hALK in complex with compound 7 N-((1S)-1-(5-fluoropyridin-2-yl)ethyl)-1-(5-methyl-1H-pyrazol-3-yl)-3-(oxetan-3-ylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-6-amine

hALK in complex with compound 7 N-((1S)-1-(5-fluoropyridin-2-yl)ethyl)-1-(5-methyl-1H-pyrazol-3-yl)-3-(oxetan-3-ylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-6-amine Descriptor: ALK tyrosine kinase receptor, N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-1-(5-methyl-1H-pyrazol-3-yl)-3-[(oxetan-3-yl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-6-amine Authors: Lane, W, Saikatendu, K. Deposit date: 2018-07-06 Release date: 2019-05-01 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.303 Å) Cite: Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors. J.Med.Chem., 62, 2019

与化合物7 N-[(1S)-1-(5-氟吡啶-2-基)乙基]-1-(5-甲基-1H-吡唑-3-基)-3-(氧杂环丁烷-3-基磺酰基)-1H-吡咯并[2,3-b]吡啶-6-胺结合的人源ALK（hALK）。
描述信息：ALK酪氨酸激酶受体，N-[(1S)-1-(5-氟吡啶-2-基)乙基]-1-(5-甲基-1H-吡唑-3-基)-3-[(氧杂环丁烷-3-基)磺酰基]-1H-吡咯并[2,3-b]吡啶-6-胺。
作者：Lane, W、Saikatendu, K.
提交日期：2018-07-06
发布日期：2019-05-01
最后修改日期：2024-03-13
实验方法：X射线衍射（分辨率2.303 Å）
引用文献：《强效、选择性且可穿透血脑屏障的1H-吡唑-5-基-1H-吡咯并[2,3-b]吡啶类ALK抑制剂》，《Journal of Medicinal Chemistry》，2019年，第62卷。