Gene expression in malignant peripheral nerve sheat tumours and benign neurofibromas. Homo sapiens

No consensus treatment regime exists beyond surgery for malignant peripheral nerve sheath tumours (MPNST), and the purpose of the present study was to find new approaches to stratify patients with good and poor prognosis and to better guide therapeutic intervention for this aggressive soft tissue cancer. Overall design: Genome-wide RNA expression was analysed for 30 MPNSTs and eight neurofibromas from Scandinavian patients, and the overall gene expression in these two groups were compared in order to identify prognostic markers.

针对恶性周围神经鞘膜瘤（MPNST），目前除手术治疗外暂无公认的标准化治疗方案。本研究旨在探索可对该侵袭性软组织癌症患者进行预后分层、区分预后良好与不良群体的新方法，以更好地指导此类患者的治疗干预。实验整体设计：对来自斯堪的纳维亚患者的30例恶性周围神经鞘膜瘤标本及8例神经纤维瘤标本开展全基因组RNA表达谱分析，并比较两组的整体基因表达水平，以期识别预后标志物。