Metadata record for the manuscript: Ivermectin converts cold tumors hot and synergies with immune checkpoint blockade for treatment of breast cancer

<b>Summary</b> This metadata record provides details of the data supporting the claims of the related manuscript: “Ivermectin converts cold tumors hot and synergies with immune checkpoint blockade for treatment of breast cancer ”. The related study shows that treatment with the FDA-approved anti-parasitic drug ivermectin induces immunogenic cancer cell death (ICD) and robust T cell infiltration into breast tumours. Type of data: tumour size measurements, flow cytometry, histology Subject of data: 4T1 cell line, BALB/c (<i>Mus musculus</i>) <b>Data access</b> The flow cytometry data (fluorescence-activated cell sorting--FACS) are available upon request from the corresponding author. Other data generated as part of the related study are tumour size measurements and histology. These are available upon request from the corresponding author. <b>Corresponding author(s) for this study</b> Peter P. Lee, M.D., Dept. of Immuno-Oncology, City of Hope and Beckman Research Institute, Beckman Center, room 5117, 1500 East Duarte Road, Duarte, CA 91010. Email: [e-mail]. <br> <b>Study approval </b> All procedures were performed under approval from City of Hope’s Animal Care and Use Committee.

<b>数据摘要</b> 本元数据记录详细说明了支撑相关论文《伊维菌素将冷肿瘤转化为热肿瘤并与免疫检查点阻断疗法协同治疗乳腺癌》的实验数据。相关研究表明，经美国食品药品监督管理局（FDA）批准的抗寄生虫药物伊维菌素治疗可诱导免疫原性癌细胞死亡（ICD），并促使大量T细胞浸润乳腺肿瘤。数据类型：肿瘤体积测量数据、流式细胞术数据、组织病理学数据。数据受试对象：4T1细胞系、BALB/c小鼠（<i>Mus musculus</i>）。<br><b>数据获取方式</b> 本流式细胞术数据（即荧光激活细胞分选术，FACS）可向通讯作者申请获取。本相关研究中产生的其余数据包括肿瘤体积测量数据与组织病理学数据，同样可向通讯作者申请获取。<br><b>本研究通讯作者</b> Peter P. Lee，医学博士，希望之城与贝克曼研究所免疫肿瘤学系，地址：加利福尼亚州杜阿尔特市东杜阿尔特路1500号贝克曼中心5117室，电子邮箱：[e-mail]。<br><b>研究伦理审批</b> 本研究所有实验操作均经希望之城动物护理与使用委员会批准后方可实施。