含药递送系统的骨软骨修复支架材料的体外药物释放特征检测报告、原始数据

含药递送系统的体外药物释放特征检测包括：检测A10E在PLGA/TCP中的负载率，并按0.1g/ml的浸泡于PBS中进行体外降解实验，收集不同时间点的降解释放液，采用HLPC检测释放液中的A10E浓度，并在检测终点12周时，检测降解支架中剩余A10E浓度。检测结果表达，A10E在PLGA/TCP中的负载率可达75%以上，在生理性溶液中展示了缓释特点， 释放周期大于12周，并检测到12周时降解支架中A10E剩余量约12%。

In vitro drug release characterization of the drug delivery system includes: determination of the loading efficiency of A10E in PLGA/TCP; in vitro degradation experiments by immersing the system in PBS at a ratio of 0.1 g/mL; collection of degradation release solutions at different time points; detection of A10E concentration in the release solutions using HLPC; and measurement of the residual A10E concentration in the degraded scaffold at the detection end point (12 weeks). The results indicate that the loading efficiency of A10E in PLGA/TCP can reach more than 75%, showing sustained-release characteristics in physiological solution with a release period longer than 12 weeks; and the residual amount of A10E in the degraded scaffold at 12 weeks was detected to be approximately 12%.