Identification of a Cluster of Calcification-Specific Valve Interstitial Cells in Calcific Aortic Valve Disease

Combined analysis of spatial and single-cell transcriptomic data provides deep insights into the pathogenesis of CAVD and reveals a cluster of csVICs. The csVIC marker genes are promising therapeutic targets for pharmaceutic interventions against CAVD.

对空间与单细胞转录组学数据的联合分析，为钙化性主动脉瓣疾病（Calcific Aortic Valve Disease, CAVD）的发病机制提供了深刻洞察，并鉴定出一类csVICs亚群。csVICs的标记基因是针对CAVD开展药物干预的极具潜力的治疗靶点。