Malignant Peripheral Nerve Sheath Tumors are Comprised of Two Epigenetic Subgroups with Distinct Molecular Landscapes, Outcomes and Therapeutic Targets: snRNA Seq Samples

We focused on studying the methylation signature of the spectrum of PNSTs to develop a methylome-based classification of these common tumors. We studied the genome-wide DNA methylation patterns using the Illumina MethylationEPIC array and classified the samples into 5 subgroups. Gene Expression comparing the subgroups were performed using single nuclear RNA Seq Single nuclear RNA profiling analysis for different methylation subgroups of PNSTs.

本研究聚焦于周围神经鞘瘤（Peripheral Nerve Sheath Tumors, PNSTs）谱系的甲基化特征，旨在建立基于甲基化组的该类常见肿瘤的分类方法。研究通过Illumina MethylationEPIC芯片分析全基因组DNA甲基化模式，将样本划分为5个亚组。针对不同甲基化亚组的PNSTs，采用单核RNA测序（single nuclear RNA Seq）开展亚组间基因表达对比及单核RNA谱分析。