PCOS

Polycystic ovarian syndrome (PCOS) is a chronic disorder with a prevalence of 10% in women worldwide and its etiology still remains poorly understood. Insulin resistance is believed to be a main pathogenic factor involved in metabolic disturbances of PCOS. Butyrylcholinesterase (BuChE) has been shown to be linked with insulin resistance, type 2 diabetes and metabolic syndrome. Reduced activity of paraoxonase 1 (PON1) has also been reported in susceptibility to insulin resistance and the other metabolic diseases. It was to evaluate the enzymatic activity of BuChE, PON1 and their association with insulin resistance in PCOS women. In this case-control study, 56 PCOS women as the case group and 62 non-PCOS women as the control group were enrolled. Menstrual status, metabolic parameters such as fasting blood insulin (FINS), fasting blood sugar (FBS), homeostatic model assessment of insulin resistance (HOMA-IR), body mass index (BMI) was measured. Enzymatic activity of BuChE and PON1 was also measured. PCOS women had significantly higher menstrual irregularity (P=0.001), FINS (P=0.018), HOMA-IR (P=0.034) and BuChE activity (P=0.004) and lower PON1 activity (P = 0.006) than control. In PCOS women, BuChE was significantly correlated with BMI. In Insulin resistant women, BuChE activity was significantly higher in PCOS than control (P=0.012). No significant relationship was found between BuChE and PON1 activity in PCOS patients (P = 0.07). These results indicate that higher BuChE and lower PON1 activity are associated with pathogenesis of PCOS and insulin resistance could be a link for this connection.

多囊卵巢综合征（Polycystic ovarian syndrome, PCOS）是一种慢性疾病，全球女性患病率达10%，但其病因学机制至今仍未完全阐明。胰岛素抵抗被认为是参与多囊卵巢综合征代谢紊乱的核心致病因素。丁酰胆碱酯酶（Butyrylcholinesterase, BuChE）已被证实与胰岛素抵抗、2型糖尿病及代谢综合征密切相关。另有研究显示，对氧磷酶1（paraoxonase 1, PON1）活性降低会增加胰岛素抵抗及其他代谢性疾病的患病风险。本研究旨在探讨多囊卵巢综合征女性体内BuChE与PON1的酶活性，并分析二者与胰岛素抵抗的关联。本项病例对照研究共纳入56名多囊卵巢综合征女性作为病例组，62名非多囊卵巢综合征女性作为对照组。研究人员记录了受试者的月经状态，并检测了多项代谢指标，包括空腹胰岛素（fasting blood insulin, FINS）、空腹血糖（fasting blood sugar, FBS）、胰岛素抵抗稳态模型评估指数（homeostatic model assessment of insulin resistance, HOMA-IR）及体质量指数（body mass index, BMI），同时测定了BuChE与PON1的酶活性。与对照组相比，病例组女性的月经不规则发生率显著更高（P=0.001），空腹胰岛素水平（P=0.018）、胰岛素抵抗稳态模型评估指数（P=0.034）及BuChE活性（P=0.004）均显著升高，而PON1活性显著降低（P=0.006）。在多囊卵巢综合征女性中，BuChE活性与体质量指数呈显著正相关。在胰岛素抵抗女性亚组中，多囊卵巢综合征患者的BuChE活性显著高于对照组（P=0.012）。在多囊卵巢综合征患者中，未发现BuChE与PON1活性存在显著关联（P=0.07）。本研究结果显示，BuChE活性升高与PON1活性降低均与多囊卵巢综合征的发病机制相关，而胰岛素抵抗可能是二者关联的潜在中介环节。