Altered Outer Retinal Structure, Electrophysiology and Visual Perception in Parkinson’s Disease Study Dataset

This dataset is from a pilot cross-sectional study where we considered whether clinically implementable measures targeting outer retinal function and structure can differentiate Parkinson's disease (PD) from healthy ageing in a similar manner to previously reported inner retinal outcomes. As a proof of principle, we also considered whether outer retinal biomarkers are sensitive to patients’ standard intraday levodopa (L-DOPA) dosing regimen. Sixteen people with PD and 21 age-matched controls (aged 41-85 years) participated in this study. Centre-surround perceptual contrast suppression, macular visual field sensitivity, colour discrimination, light-adapted electroretinography and optical coherence tomography were tested. Electroretinography and optical coherence tomography were conducted twice during the visit: before and after a midday L-DOPA dose for PD participants, or repeated after approximately two hours for control participants.

本数据集来源于一项初步横断面研究，旨在探究针对视网膜外层功能与结构的临床可实施测量方法，是否能像先前报道的视网膜内层结果那样，有效区分帕金森病（PD）患者与健康老龄化人群。作为原理验证，我们还考察了视网膜外层生物标志物是否对患者标准日内左旋多巴（L-DOPA）给药方案敏感。16名PD患者与21名年龄匹配的对照者（年龄41-85岁）参与了本研究。研究测试了中心-周围知觉对比抑制、黄斑视野敏感度、颜色辨别能力、光适应视网膜电图以及光学相干断层扫描。视网膜电图和光学相干断层扫描在访视期间进行了两次：PD患者在午间L-DOPA给药前后各一次，对照者则在约两小时后重复测试。