High Density SNP Association Analysis of Melanoma: Case-Control and Outcomes Investigation. Homo sapiens

This research builds upon an extensive resource of melanoma cases and hospital based controls collected over several years at the U.T. M.D. Anderson Cancer Center. The goal of this research is to identify novel susceptibility and outcome-related genes for melanoma using a systematic genome-wide association-based approach. Our goal is to conduct high-density SNP association and outcome studies. This dbGaP study contains samples from 2000 European ancestry cases and 1000 European ancestry controls using the Illumina OMNI1-Quad SNP chip. As a part of an ongoing R01 project, we have epidemiological data together with candidate gene results for 1000 of the melanoma cases and the controls. With regard to the outcome aspect of our design, as part of our melanoma Specialized Program of Research Excellence (SPORE) grant, our MelCore database contains comprehensive, prospectively maintained clinical information from all melanoma patients included in the study cohort... (for more see dbGaP study page.)

本研究依托德克萨斯大学MD安德森癌症中心（U.T. M.D. Anderson Cancer Center）多年来采集的海量黑色素瘤病例与医院来源对照样本资源开展。本研究旨在通过系统性全基因组关联研究方法，筛选黑色素瘤新型易感基因及预后相关基因，计划开展高密度单核苷酸多态性（Single Nucleotide Polymorphism, SNP）关联分析与预后研究。本dbGaP研究采用Illumina OMNI1-Quad SNP芯片，纳入了2000名欧洲血统黑色素瘤病例与1000名欧洲血统对照样本。作为一项在研R01项目的组成部分，我们已获取1000例黑色素瘤病例及对照样本的流行病学数据与候选基因研究结果。针对研究设计中的预后维度，依托黑色素瘤卓越研究专项计划（Specialized Program of Research Excellence, SPORE）资助项目，我们的MelCore数据库收录了研究队列中所有黑色素瘤患者的全面前瞻性维护临床信息……（更多详情请参阅dbGaP研究页面）