Spatially resolved transcriptomes of healthy mammalian kidneys illustrate the molecular complexity and interactions of functional nephron segments

We performed spatial transcriptomics sequencing (ST-seq) to resolve geographically defined transcriptome-wide gene expression within the tissue context of four human and six mouse kidneys. This application of ST-seq within healthy mammalian kidneys demonstrates the integration of transcriptional profiles with histology, and is a valuable data resource for the kidney community.我们开展了空间转录组测序（spatial transcriptomics sequencing，ST-seq），旨在解析4个人类肾脏与6只小鼠肾脏的组织微环境中，经地理区域界定的全转录组基因表达谱。本研究将ST-seq应用于健康哺乳动物肾脏，证实了转录谱与组织学特征的整合，可为肾脏研究领域提供极具价值的数据资源。