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Concordance of results for the DNA strip test (GenoType LepraeDR) and the susceptibility phenotypic and genotypic pattern of antibiotic resistance for the M. leprae strains studied.

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Figshare2015-12-02 更新2026-04-29 收录
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*For strains growing in vivo and yielding interpretable susceptibility results. Tests were stopped for dapsone due to new regulation for antibiotic animal feeding. Tests for ofloxacin were restricted to patient with previous treatment by fluoroquinolones.**including two strains with a mutation at codon 447: Ser447Cys for one strain and a silent mutation for the second strain (see text for details).

* 适用于体内生长且药敏结果可被准确解读的菌株。因兽用抗生素相关新监管规定,已停止氨苯砜(dapsone)的检测。氧氟沙星(ofloxacin)的检测仅限定于既往接受过氟喹诺酮类药物治疗的患者。** 包含两株第447位密码子(codon)发生突变的菌株:其中一株为Ser447Cys突变(即第447位丝氨酸突变为半胱氨酸),另一株为沉默突变,详细信息见正文。
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2015-12-02
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