Data in support of nutrition for improved growth and health of very preterm infants

Impaired growth and nutrition after preterm birth is associated with morbidities and poor neurodevelopmental outcome, but it is not clear whether this reflects causal relationships. To improve growth, human milk is often fortified with protein, energy and minerals, providing small, but significant, fortification-induced gains in body weight, length and/or head circumference. the effect of Bovine Colostrum fortification on AAs and proteins in plasma, and how fortification-induced AA changes during the first two weeks of fortification associated with changes in anthropometric measures, gestational age (GA) at birth, birth weight, key morbidities (BPD, ROP, LOS) and IGF-1 levels. Collectively, the analyses shed light on the complex interplay between fortification-induced changes to plasma AA/protein levels and the growth and morbidities in very preterm infants fed fortified human milk.

早产婴儿出生后出现的生长与营养障碍，与多种并发症及不良神经发育结局密切相关，但目前尚未明确二者是否存在直接因果关联。为改善此类患儿的生长状况，临床常通过添加蛋白质、能量与矿物质对人乳进行强化，该操作可使婴儿的体重、身长及/或头围获得小幅但具有统计学意义的强化诱导增长。本数据集聚焦于牛初乳强化（Bovine Colostrum fortification）对血浆氨基酸（Amino Acids, AAs）与蛋白质水平的影响，并探究强化干预前两周内，由强化诱导产生的血浆AA变化，如何与体格测量指标变化、出生胎龄（Gestational Age, GA）、出生体重、关键并发症（支气管肺发育不良（Bronchopulmonary Dysplasia, BPD）、早产儿视网膜病变（Retinopathy of Prematurity, ROP）、晚发性败血症（Late-Onset Sepsis, LOS））及胰岛素样生长因子1（Insulin-like Growth Factor 1, IGF-1）水平的变化相关联。综上，本研究的各项分析阐明了接受强化人乳喂养的极早早产儿中，强化诱导的血浆AA/蛋白质水平变化与生长状况及并发症之间的复杂相互作用。