NIDDK IBD Genetics Consortium Crohn's Disease Genome-Wide Association Study . NIDDK IBD Genetics Consortium Crohn's Disease Genome-Wide Association Study

This dataset contains data from a genome-wide association study performed with 968 Inflammatory Bowel Disease (IBD) affected cases and 995 unrelated controls using the Illumina HumanHap300 Genotyping BeadChip. Cases were selected to have Crohn's disease with ileal involvement, and controls were matched to cases based on sex and year of birth. Subjects were drawn from two cohorts: (1) persons with non-Jewish, European ancestry (561 cases and 563 controls), and (2) persons with Jewish ancestry (407 cases and 432 controls). Genotyping was performed at the Feinstein Institute for Medical Research. Seven-hundred fifty-four of the samples (468 cases and 286 controls) were taken from the NIDDK IBD Genetics Consortium cell line repository. These samples are identified in the IBD_Sample file. The subject IDs for these individuals may be used to request corresponding samples for follow-up research through the repository. In addition, complete phenotype data for... (for more see dbGaP study page.)

本数据集包含基于Illumina HumanHap300基因分型芯片（Illumina HumanHap300 Genotyping BeadChip）开展的全基因组关联研究数据，研究纳入968例炎症性肠病（Inflammatory Bowel Disease, IBD）患者组成的病例组与995名无关健康对照个体。病例组均为伴回肠受累的克罗恩病（Crohn's disease）患者，对照组则按照性别与出生年份与病例组进行匹配。研究对象来自两个队列：(1) 非犹太裔欧洲血统人群（561例病例、563名对照）；(2) 犹太裔血统人群（407例病例、432名对照）。基因分型实验在范斯坦医学研究所（Feinstein Institute for Medical Research）完成。其中754份样本（468例病例、286名对照）取自美国国家糖尿病、消化和肾脏疾病研究所炎症性肠病遗传学联盟（National Institute of Diabetes and Digestive and Kidney Diseases Inflammatory Bowel Disease Genetics Consortium, NIDDK IBD Genetics Consortium）的细胞系库，此类样本在IBD_Sample文件中均有标注。研究者可通过该库，凭借这些个体的受试者编号申请用于后续研究的对应样本。此外，本数据集包含完整的表型数据……（更多详情请参阅dbGaP研究页面）