Faecal and colonic mucosa microbiota of interleukin-10-deficient mice and WT controls

To study the natural history of ileocolitis in IL-10 deficient mice, and unravel the influence of intestinal barrier dysfunction and dysbiosis in the development of overt inflammation.

本研究旨在探究白细胞介素10（IL-10）缺陷小鼠回结肠炎的自然病程，并阐明肠道屏障功能障碍与菌群失调对显性炎症发生发展的影响。