ChIP-seq H3K9ac in sea cucumber

We presented a genome-wide characterization for H3K9 acetylation (H3K9ac) binding regions in normal temperature and heat-stress conditions via ChIP-seq. The results revealed H3K9ac was an extensive epigenetic modulation in A. japonicus. We further identified differentially acetylated regions (DARs) under heat stress. Examination of H3K9ac in control and heat-stress groups in intestine tissue of Apostichopus japonicus

本研究通过染色质免疫共沉淀测序（ChIP-seq），对正常温度与热应激条件下刺参（Apostichopus japonicus）体内H3K9乙酰化（H3K9ac）结合区域开展了全基因组范围的表征分析。研究结果显示，H3K9ac是刺参中广泛存在的表观遗传调控模式。本研究进一步鉴定了热应激条件下的差异乙酰化区域（DARs），并针对刺参肠道组织的对照组与热应激组样本完成了H3K9ac检测分析。