List of positions located in the 7-TMs and EL2 of rhodopsin (Rho).

beta-2 adrenergic receptor (β2-AR) and adenosine receptor (A2A) that are in contact with the co-crystallized ligand (underlined) and/or qualified as key positions (in bold and marked with an X). The MI data refer to the analysis performed on a subset of class A receptor adding to the MSA of the 7-TMs the alignment of five EL2 positions. The position has highest MI (among all other inter-TM positions) with the listed pair position (pp). Rank is the MI ranking of that pair using a subset of class A 7-TM along with EL2 MSA (249 sequences) the degree is calculated using MI graph from top 700 MI pairs. Entropy and MI are measured in bits.

β2肾上腺素能受体（beta-2 adrenergic receptor, β2-AR）与腺苷受体（adenosine receptor, A2A）的相关位点包括两类：与已下划线标注的共结晶配体相互作用的位点，以及被标注为关键位点的位点（粗体标注并带有X标记）。本数据集的互信息（Mutual Information, MI）数据基于A类受体的一个子集分析得到：在7次跨膜结构域（7-transmembrane domains, 7-TMs）的多序列比对（multiple sequence alignment, MSA）基础上，额外加入了5个胞外环2（extracellular loop 2, EL2）位点的比对序列。该位点与所列配对位点（pp）之间的MI值在所有跨膜结构域间位点中最高。排名（Rank）指基于包含249条序列的A类7-TMs及EL2的MSA子集，计算得到的该配对的MI排名；节点度（degree）则通过取自前700个MI对的互信息图计算得出。熵（Entropy）与互信息（MI）的计量单位为比特（bits）。