The uterine secretory cycle: shifts to the recurring physiology of endometrial outputs in the presence of a preimplantation embryo

The bovine endometrium secretes proteins during early pregnancy that vary (in both protein identity and abundance) to be in synchrony with luminal reproductive events. To uncover the identity of these proteins, transcriptomics was performed to understand the secretory capability of the bovine endometrium through the distinct phases of early pregnancy in virgin heifers. This dataset should serve as a baseline for understanding the profile of luminal secretory outputs during early pregnancy, setting the stage for functional interpretation of how the uterus supports and directs biological events ranging from sperm transport to preimplantation embryo development.

牛子宫内膜在早期妊娠阶段会分泌蛋白质，此类蛋白质的种类与丰度均会发生动态变化，以与宫腔内的生殖进程保持同步。为明确此类蛋白质的具体种类，本研究针对未受孕青年母牛早期妊娠的不同时期开展转录组学分析，以解析牛子宫内膜的分泌能力。本数据集可作为解析早期妊娠宫腔分泌产物谱的基准参照，为阐释子宫如何支持并调控从精子运输到着床前胚胎发育的一系列生物学事件奠定研究基础。