Data Sheet 1_Quality-of-life survey of pancreatic cancer patients: a comparison between general public and physicians.docx

BackgroundQuality-of-life (QOL) is important for cancer patients with poor prognosis. However, conducting a QOL survey with patients is difficult. Therefore, we conducted a QOL survey with physicians. Specifically, this study aimed to clarify how physicians assess QOL in patients with pancreatic cancer by conducting a survey and comparing the results between physicians and the general public.
MethodsA survey was conducted by interviewing physicians administering chemotherapy to patients for recurrent/metastatic pancreatic cancer. This method is similar to that of the QOL survey conducted among the general public. Responses were evaluated using the composite time trade-off (cTTO) and the visual analog scale (VAS) for 11 pancreatic cancer status scenarios (survey scenarios). These scenarios consisted of patients’ health states as well as the types and grades of adverse events (AEs). Health status was classified into two categories: Stable disease (SD) and Progressive disease (PD). In addition, we conducted a survey using the EuroQol 5 Dimensions 5-Level (EQ-5D-5l) as reference values.
ResultsTwenty physicians responded to the survey. SD had the highest mean QOL value for both assessment methods (Physicians: 0.78, General public: 0.63), whereas PD had the lowest mean QOL value (Physicians: 0.15, General public: −0.12). The physicians assigned higher QOL values on both the VAS and cTTO than the general public did in all survey scenarios.
ConclusionsThe QOL values obtained from physicians were consistent with the degree of status in any assessment scenarios. Based on the differences in the QOL survey results between physicians and the general public, physicians tended to assign higher QOL values than the general public in cTTO and VAS assessments.

背景 生活质量（Quality of Life, QOL）对于预后不良的癌症患者而言至关重要。然而，直接对患者实施生活质量调查存在诸多困难。因此，本研究转而面向医师开展生活质量调查。具体而言，本研究旨在通过问卷调查明确医师如何评估胰腺癌患者的生活质量，并对比医师与普通大众的调查结果差异。
方法 本研究对为复发/转移性胰腺癌患者实施化疗的医师开展访谈式调查。该调查方法与面向普通大众开展的生活质量调查方法保持一致。针对11种胰腺癌病情场景（调查场景），研究采用综合时间权衡法（Composite Time Trade-off, cTTO）与视觉模拟评分法（Visual Analog Scale, VAS）对受访者的回答进行评估。上述场景涵盖患者健康状态、不良反应（Adverse Events, AEs）的类型与分级。健康状态分为两类：疾病稳定（Stable Disease, SD）与疾病进展（Progressive Disease, PD）。此外，本研究采用欧洲五维健康量表5级版（EuroQol 5 Dimensions 5-Level, EQ-5D-5L）作为参考标准开展调查。
结果 共有20名医师参与了本次调查。在两种评估方法下，疾病稳定（SD）的平均生活质量得分均为最高（医师组：0.78，普通大众组：0.63），而疾病进展（PD）的平均生活质量得分均为最低（医师组：0.15，普通大众组：-0.12）。在所有调查场景中，医师在VAS与cTTO评估中给出的生活质量得分均高于普通大众。
结论 本研究获取的医师评分与各类评估场景下的病情严重程度相符。基于医师与普通大众的生活质量调查结果差异，医师在cTTO与VAS评估中倾向于给出高于普通大众的生活质量得分。