Development of microRNA (miRNA) expression signatures for human glioma-initiating cells (GICs). Homo sapiens

To identify a novel miRNA that is aberrantly expressed in GICs, we analyzed differences in miRNA expression between the human GICs and glioma cell lines and neural stem cells by miRNA microarrays. Overall design: We examined the miRNA expression profiles of five human GICs that were obtained from human glioma samples and two human glioma cell lines, U87 and U251, and NSC (neural stem cells) as a control.

为鉴定在胶质瘤起始细胞（Glioma Initiating Cells，GICs）中异常表达的新型微小RNA（microRNA，miRNA），我们通过miRNA微阵列（miRNA microarray）分析了人GICs、胶质瘤细胞系与神经干细胞之间的miRNA表达差异。
实验整体设计：我们对5株从人脑胶质瘤样本中分离得到的人GICs、2株人胶质瘤细胞系U87、U251，以及作为对照的神经干细胞（neural stem cells，NSC）的miRNA表达谱进行了检测。