Data_Sheet_1_Role of Dectin-1 in peripheral nerve injury.PDF

Dectin-1, a C-type lectin receptor, plays a role in nerve injury in the central nervous system. However, whether it plays a role in the peripheral nervous system is not well understood. Our study showed the expression of Dectin-1 on the membrane of macrophages. We also used a sciatic nerve crushing injury model to demonstrate that there was a delay in nerve degeneration-related processes such as breakdown of injured myelinated nerve fibers and formation of myelin ovoid in groups injected with whole glucan particle soluble (WGPS), a Dectin-1 antagonist. There were also fewer intraneural blood vessels in the Dectin-1 antagonist treated group. Our study suggested inhibiting Dectin-1 delayed debris clearance, nerve degeneration, and angiogenesis after peripheral nerve injury.

Dectin-1是一种C型凝集素受体（C-type lectin receptor），可参与中枢神经系统的神经损伤过程，但其在周围神经系统中的功能尚未明确。本研究检测到Dectin-1表达于巨噬细胞膜表面；通过坐骨神经压榨损伤模型进一步证实，注射可溶性全葡聚糖颗粒（whole glucan particle soluble, WGPS，一种Dectin-1拮抗剂）的实验组中，受损有髓神经纤维崩解、髓鞘卵圆形小体形成等神经退变相关进程均出现延迟，且该组的神经内血管数量亦显著减少。本研究结果提示，抑制Dectin-1可延缓周围神经损伤后的碎片清除、神经退变与血管生成过程。