CircRNAs expression profile in Mus musculus pre-metastatic lungs. CircRNAs expression profile in Mus musculus pre-metastatic lungs

Our research aims to chart the circRNA expression profile and assess their impact on the lung PMN. We developed a lung PMN model and employed comprehensive RNA sequencing to analyze the differences in circRNA expression between normal and pre-metastatic lungs.Overall, our study highlights the crucial role of circRNAs in the formation of lung PMNs, supporting their potential as diagnostic or therapeutic targets for lung metastasis. Overall design: We developed a lung PMN model and employed comprehensive RNA sequencing to analyze the differences in circRNA expression between normal and pre-metastatic lungs.

本研究旨在描绘环状RNA（circular RNA, circRNA）的表达谱，并评估其对肺PMN的影响。我们建立了肺PMN模型，并采用RNA测序（RNA sequencing）分析正常肺与转移前肺组织中环状RNA的表达差异。总体而言，本研究揭示了环状RNA在肺PMN形成过程中的关键作用，支持其作为肺转移诊断或治疗靶点的潜在价值。实验设计概述：我们建立了肺PMN模型，并采用RNA测序（RNA sequencing）分析正常肺与转移前肺组织中环状RNA的表达差异。