Axl targeting in experimental unilateral ureteral obstruction. Axl targeting in experimental unilateral ureteral obstruction

We investigated if Axl receptor tyrosine kinase was up-regulated in unilateral ureteral obstruction (UUO) and if blocking of Axl by a small molecule called BGB324 (also called Bemcentinib) reduces fibrosis development in the ligated kidney as compared to treatment with its vehicle alone. Overall design: Two treatment groups of C57Bl/6JOaHSD mice (both groups n=6), which were treated with either BGB324/Bemcentinib or its vehicle (0.5% hydroxylpropyl-methylcellulose in 0.1% Tween 80).

本研究旨在探究单侧输尿管梗阻（UUO）模型中Axl受体酪氨酸激酶（Axl receptor tyrosine kinase）是否存在表达上调，并对比仅接受溶媒处理的组别，采用小分子化合物BGB324（又名Bemcentinib）阻断Axl后，能否减轻结扎侧肾脏的纤维化进程。实验设计概述：将C57Bl/6JOaHSD小鼠分为两组（每组n=6），分别接受BGB324/Bemcentinib或其溶媒（0.5%羟丙基甲基纤维素溶于0.1%吐温80溶液）处理。