Are the blood pressure levels associated with the hippocampal, temporal and amygdala volumes in sedentary females? A sub-group analysis of a cross-sectional study

This study investigated the impact of sedentary behavior and hypertension on brain size, focusing on the female population, with a retrospective analysis of MRI data from 19 sedentary females. The results revealed a significant relationship between hypertension and brain structure changes, particularly an enlargement of the hippocampal region in hypertensive females, which was most pronounced in early stages of hypertension but less pronounced in more advanced stages. These findings underscore the importance of monitoring hypertension, as it can silently affect cognitive health, emphasizing the need for early detection and management to prevent cognitive decline in individuals with sedentary lifestyles, especially females. Further research is needed to understand the underlying mechanisms and clinical implications of these cerebral alterations.本研究以女性群体为核心研究对象，探讨久坐行为与高血压对脑体积的影响，对19名久坐女性的核磁共振成像（MRI）数据开展回顾性分析。研究结果显示，高血压与脑结构变化存在显著关联：高血压女性的海马体区域出现扩大现象，该改变在高血压早期最为显著，而在病情进展至晚期时则相对不明显。上述发现凸显了高血压监测的重要性——高血压可隐匿性地影响认知健康，同时强调了早检测、早干预的必要性，以预防久坐人群（尤其是女性）出现认知衰退。未来仍需开展进一步研究，以阐明此类脑结构改变的潜在机制与临床应用价值。