To establish cancer cells escaping from host immunity, we used murine B16 melanoma cell line expressing ovalbumin (B16OVA) and inoculated into mice immunized with OVA. Using this model, we established
In normal skin, interactions between melanocytes and keratinocytes, and between melanocytes and the basal membrane are functionally relevant for maintenance of homeostasis and epidermal melanin unit w
Among hallmarks of cancer is impaired proteostasis, that is characterized by increased oncoprotein stability. Here we demonstrate that RNF4, a ubiquitin ligase implicated in the stabilization of shor
