Patient characteristics (n = 70).
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PRES, Posterior Reversible Encephalopathy syndrome; CT, computed tomography; MRI, magnetic resonance imaging; ICU, Intensive Care Unit; SAPS, Simplified Acute Physiology Score; [26] GCS, Glasgow Coma Scale score [14], [15].Age (yr): 38±15 (Mean ± sd).ΣLumbar puncture, n = 40 (57%); Average Cell count (number/µL): 17 (range, 0–320); average glucose (mmol/L): 4.1 (range, 0.6–6.6); average protein (g/L): 0.81 (range, 0.25–4.2).‡CT scan only, n = 12 (17%); MRI only, n = 25 (36%); CT scan and MRI, n = 33 (47%).ФRefractory status epilepticus was defined as continuous or intermittent seizures despite treatment with an intravenous benzodiazepine (clonazepam or diazepam) and intravenous phenytoin, fosphenytoin, or phenobarbital [19].†Electrical status epilepticus was diagnosed when the patient was found in a coma with or without subtle convulsive movements but with generalized or lateralized ictal discharges on the electroencephalogram (n = 59). [21].£Reversibility was partial in 21 (43%) and total in 22 (45%) patients.Ψamong patients with follow-up imaging studies, n = 49 (70%).Θhaemorrhagic, n = 6 (12%); ischaemic, n = 4 (8.2%) (A given patient could have more than one complication.).‡Four deaths directly ascribable to PRES: one patient each had brain death related to cardiac arrest complicating the treatment of status epilepticus, refractory status epilepticus with multi-organ failure, cerebral haemorrhage with ventricular flooding, and brain death related to cerebral herniation complicating cerebral ischaemia.
后部可逆性脑病综合征(Posterior Reversible Encephalopathy syndrome, PRES);计算机断层扫描(computed tomography, CT);磁共振成像(magnetic resonance imaging, MRI);重症监护病房(Intensive Care Unit, ICU);简化急性生理学评分(Simplified Acute Physiology Score, SAPS);格拉斯哥昏迷量表评分(Glasgow Coma Scale score, GCS)[14,15,26]。年龄(岁):38±15(均值±标准差)。腰椎穿刺例数:40例(57%);平均细胞计数(个/μL):17(范围:0~320);平均葡萄糖浓度(mmol/L):4.1(范围:0.6~6.6);平均蛋白浓度(g/L):0.81(范围:0.25~4.2)。‡仅行CT扫描者:12例(17%);仅行MRI者:25例(36%);同时行CT与MRI者:33例(47%)。Ф难治性癫痫持续状态的定义为:经静脉使用苯二氮䓬类药物(氯硝西泮或地西泮)及静脉苯妥英、磷苯妥英或苯巴比妥治疗后,仍出现持续或间歇性癫痫发作者[19]。†电发作性癫痫持续状态的诊断标准为:患者处于昏迷状态,伴或不伴轻微抽搐运动,但脑电图可见全面性或偏侧性发作样放电,共59例[21]。£21例(43%)患者的影像学异常为部分可逆,22例(45%)患者的影像学异常完全可逆。Ψ行影像学随访检查的患者共49例(70%)。Θ出血性并发症6例(12%),缺血性并发症4例(8.2%),同一名患者可合并多种并发症。‡因PRES直接导致的死亡共4例:分别为癫痫持续状态治疗过程中并发心搏骤停所致脑死亡、伴多器官衰竭的难治性癫痫持续状态、伴脑室充盈的脑出血、脑缺血并发脑疝所致脑死亡。
创建时间:
2015-12-02



