RNA-Sequencing of Acute interstitial pneumonia compared with Control Lung. RNA-Sequencing of Acute interstitial pneumonia compared with Control Lung

Acute Interstitial Pneumonia (AIP) represents a severe form of diffuse lung injury within the idiopathic interstitial pneumonia spectrum. Given the limited understanding of its molecular basis, this study aims to elucidate AIP's transcriptomic profiles to uncover its pathophysiological underpinnings and identify potential therapeutic targets. Overall design: To determine the common and unique molecular features of AIP, transcriptome analysis of lung samples from AIP (N=15), controls (N=5) was conducted. Differential gene expression was determined using p-value to control for comparison.

急性间质性肺炎（Acute Interstitial Pneumonia, AIP）是特发性间质性肺炎（idiopathic interstitial pneumonia）谱系中一类严重的弥漫性肺损伤类型。鉴于当前对其分子基础的认知较为有限，本研究旨在阐明AIP的转录组学特征，以揭示其病理生理机制，并识别潜在的治疗靶点。
总体实验设计：为明确AIP共有的与独特的分子特征，本研究对AIP患者肺组织样本（N=15）及对照样本（N=5）开展了转录组分析。通过p值控制多重比较以鉴定差异表达基因。