Sjor_mammary

Using Sleeping Beauty mutagenesis in the mouse we have performed a screen to identify mechanisms of resistance to FGF inhibitors. In this experiment we pulldown transposon insertion sites with the aim of identifying resistance mechanisms/genes.

本研究借助睡美人诱变（Sleeping Beauty mutagenesis）技术在小鼠模型中完成筛选实验，旨在鉴定成纤维细胞生长因子抑制剂（FGF inhibitors）的耐药机制。本实验通过下拉实验获取转座子插入位点（transposon insertion sites），以期明确耐药相关机制与耐药基因。