Synthesis of Glaucogenin D, a Structurally Unique Disecopregnane Steroid with Potential Antiviral Activity

The first chemical synthesis of glaucogenin D, a 13,14:14,15-disecopregnane steroid with potential antiviral activity, has been accomplished in 12 steps from a hirundigenin-type intermediate. The present route would also be amenable to the synthesis of natural and unnatural glaucogenin derivatives for SAR studies.

本研究首次实现了蓝花苷元D（glaucogenin D）的化学全合成，该化合物为一类具有潜在抗病毒活性的13,14:14,15-双断孕甾烷类固醇，合成以燕苷元（hirundigenin）型中间体为起始原料，仅需12步反应即可完成。本研究所采用的合成路线同样可用于天然及非天然蓝花苷元D衍生物的制备，以支持构效关系（Structure-Activity Relationship）研究。