Adipose tissue of overfed animals during and after overfeeding

We report the transcriptomes (polyadenylated mRNAs over 200bp) of animals overfed through intragastric tubes either in the overfed state (OIO) or 24 hours after cessation of overfeeding (OIOneg). We also report transcriptomes of weight-matched mice either fed (ALO, or fasted 24 hours (ALOneg). Examination of transcriptomes in two models of weight gain at either peak weight or after 24 hours without feeding.

本研究报道了经胃管（intragastric tube）过度喂养的动物的转录组（transcriptome），所检测的靶标为长度超过200bp的多腺苷酸化信使RNA（polyadenylated mRNA），样本分为两类：一类取自过度喂养状态下（OIO），另一类取自停止过度喂养24小时后（OIOneg）。本研究同时报道了体重匹配小鼠的转录组，受试小鼠分别处于自由进食状态（ALO）以及禁食24小时状态（ALOneg）。本研究针对两种体重增加模型，分别在其体重达到峰值时刻，以及禁食24小时后的状态下对其转录组进行了检测分析。