Apoptotic auditory brainstem of E13 chick embryo

We characterized the proteome of the auditory brainstem of a chick embryo on embryonic day 13, when apoptosis occurs in auditory nuclei. We identified caspase substrates by searching the peptidome for peptides C-terminal to caspase-typical cleavage sites.

本研究对胚胎发育第13天的鸡胚听觉脑干蛋白质组进行了表征，该时间点听觉核团正发生细胞凋亡。本研究通过在肽组中检索半胱天冬酶（caspase）典型切割位点C端的肽段，鉴定出了半胱天冬酶的底物蛋白。