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Genome-wide maps of Wnt effector Tcf7l2/Tcf4 occupancy in oligodendrocyte during CNS myelination

ChEBI2016-02-19 更新2026-07-12 收录

髓鞘形成机制

胶质细胞表观遗传学

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-65119 数据链接链接失效反馈

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资源简介：

Genome-wide maps of Wnt effector Tcf7l2/Tcf4 occupancy in oligodendrocyte during CNS myelination

应用场景：

创建时间：

2016-02-19

髓鞘形成机制

胶质细胞代谢调控

In the vertebrate nervous system, myelination of axons for rapid impulse propagation requires the synthesis of large amounts of lipids and proteins by oligodendrocytes and Schwann cells. Myelin membra

NIAID Data Ecosystem90

Constitutive and Tamoxifen inducible knockout of HDAC1 and HDAC2 in Microglia. Mus musculus

胶质细胞表观遗传学

基因敲除模型

Hdac1 and 2 are important regulators of developmental processes. In this study we created microglia specific compound Hdac1 and Hdac2 knock out mice. Pre-natal ablation of both Hdac1 and 2 from microg

NIAID Data Ecosystem50

Loss of Tmem106b leads to myelination deficits: implications for FTD treatment strategies

髓鞘形成机制

痴呆治疗

Genetic variants that define two distinct haplotypes at the TMEM106B locus have been implicated in multiple neurodegenerative diseases and in healthy brain aging. In frontotemporal dementia (FTD), the

NIAID Data Ecosystem50

List of top TFs with altered binding scores.

转录因子结合分析

胶质细胞表观遗传学

ATAC-seq data from sorted control and ATRX-null microglia nuclei was analyzed to identify the top represented transcription factors binding sites displaying differential binding scores (top 2%) using

NIAID Data Ecosystem60

Disease-associated astrocyte epigenetic memory promotes CNS pathology [For 3 times stimulation and Germ Free Mice]

胶质细胞表观遗传学

神经病理机制

Disease-associated astrocyte epigenetic memory promotes CNS pathology In this study we generated ATAC-Seq data from TNF-Alpha and PBS stimulated astrocytes from Germ Free Mice and Normal Mice. Normal

NIAID Data Ecosystem50

Genome-wide maps of Wnt effector Tcf7l2/Tcf4 occupancy in oligodendrocyte during CNS myelination

资源简介：

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