Gene expression profile in Liver of 10mo old MANFHet mice

Transcriptome analysis comparing livers of 10 month old MANFHet mice and WT littermates revealed the induction of genes associated with inflammation, apoptosis, collagen deposition, usually observed in association with liver damage, along with alterations in lipid metabolism. RNA was extracted and sequenced for 8 litermates, 4 animals/genotype

通过对10月龄MANF杂合子（MANFHet）小鼠与野生型（Wild Type, WT）同窝幼鼠的肝脏开展转录组分析，研究人员发现炎症、细胞凋亡、胶原沉积相关基因出现诱导表达——这类基因通常与肝损伤相伴出现——同时伴随脂质代谢的改变。本研究共对8只同窝动物进行了RNA提取与测序，每种基因型各纳入4只实验个体。