Jelic2005_HypothalamicPituitaryAdrenal

This a model from the article:
Mathematical modeling of the hypothalamic-pituitary-adrenal system activity.

Jelic S, Cupic Z, Kolar-Anic L. Math Biosci
2005 Oct;197(2):173-87 16112688
,
Abstract:

Mathematical modeling has proven to be valuable in understanding of the complex
biological systems dynamics. In the present report we have developed an initial
model of the hypothalamic-pituitary-adrenal system self-regulatory activity. A
four-dimensional non-linear differential equation model of the hormone secretion
was formulated and used to analyze plasma cortisol levels in humans. The aim of
this work was to explore in greater detail the role of this system in normal,
homeostatic, conditions, since it is the first and unavoidable step in further
understanding of the role of this complex neuroendocrine system in
pathophysiological conditions. Neither the underlying mechanisms nor the
physiological significance of this system are fully understood yet.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Jelic S, Cupic Z, Kolar-Anic L. (2005) - version=1.0

The original CellML model was created by:
Catherine Lloyd

[e-mail]
The University of Auckland
This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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本模型来自以下论文：《下丘脑-垂体-肾上腺系统活动的数学建模》
作者：耶利奇S、库皮奇Z、科拉尔-阿尼奇L。刊载于《数学生物科学》（Math Biosci），2005年10月；第197卷第2期：173-187，PubMed编号16112688

摘要：
数学建模已被证实有助于解析复杂生物系统的动力学特性。本研究构建了首个下丘脑-垂体-肾上腺系统自调节活动的初始模型。我们建立了激素分泌的四维非线性微分方程模型，并将其用于分析人体血浆皮质醇水平。鉴于该系统是后续理解其在病理生理状态下作用的必要前提步骤，本研究旨在更细致地探究该系统在正常稳态条件下的功能。目前，该系统的潜在机制与生理意义仍未完全阐明。

本模型取自CellML模型库（CellML），并自动转换为SBML格式（SBML）。原始模型为：耶利奇S、库皮奇Z、科拉尔-阿尼奇L.（2005年），版本1.0

原始CellML模型由凯瑟琳·劳埃德创建，联系邮箱：[e-mail]，隶属于奥克兰大学。

本模型源自BioModels数据库（BioModels Database），即带注释的已发表模型数据库（http://www.ebi.ac.uk/biomodels/）。版权归2005-2011年的BioModels.net团队所有。
在法律允许的最大范围内，本编码模型的所有版权及相关邻接权利已无偿奉献至全球公共领域。更多信息请参阅CC0公共领域授权协议（CC0 Public Domain Dedication）。

简言之，您可按任意合适方式使用本编码模型，包括原样使用、修改后使用、单独使用或嵌入更大的上下文环境中，可进行再分发，无论是否用于商业用途、是否受权限限制。

若需引用BioModels数据库，请使用以下著录格式：李C、多尼泽利M、罗德里格斯N、达鲁里H、恩德勒L、切利亚伊V、李L、何E、亨利A、斯特凡MI、斯努普JL、赫卡M、勒诺弗尔N、莱布C（2010年）《BioModels数据库：针对已发表定量动力学模型的增强型精选注释资源》，《BMC系统生物学》（BMC Syst Biol.），4:92。